Description

1H-Imidazole-4-Acetic Acid, 1-(Trimethylsilyl)-, Trimethylsilyl Ester is a silylated derivative of imidazole-4-acetic acid, a compound of significant interest in advanced organic synthesis. This specialized organosilicon reagent is valued for its role as a protected intermediate, enhancing stability and solubility for complex molecular construction. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel active ingredients and high-value specialty compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic pathways.
• Peptide Mimetics & Bioconjugation: Used to introduce imidazole-like functionalities into peptides or for creating stable linkages in bioconjugate chemistry.
• Ligand Synthesis for Catalysis: Serves as a precursor for creating N-heterocyclic carbene (NHC) ligands or other coordinating agents used in transition metal catalysis.
• Material Science Research: Employed in the development of functionalized polymers, coatings, or metal-organic frameworks (MOFs) with tailored properties.
• Agrochemical Synthesis: An intermediate in the production of advanced, high-performance crop protection agents.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1H-Imidazole-4-Acetic Acid, 1-(Trimethylsilyl)-, Trimethylsilyl Ester
CAS No.	56114-70-6
Molecular Formula	C11H22N2O2Si2
Molecular Weight	270.48 g/mol
Synonyms	1-(Trimethylsilyl)imidazole-4-acetic acid trimethylsilyl ester; 4-(Trimethylsilyloxymethyl)-1-(trimethylsilyl)imidazole; Imidazole-4-acetic acid, 1-(trimethylsilyl)-, bis(trimethylsilyl) ester; 1-TMS-imidazole-4-acetic acid TMS ester; Bis(trimethylsilyl) 1-(trimethylsilyl)imidazol-4-ylacetate
EINECS	Contact for details

Quality Control

Our production of 1H-Imidazole-4-Acetic Acid, 1-(Trimethylsilyl)-, Trimethylsilyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by modern analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.