Description

1-Trimethylsilyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester is a specialized organosilicon derivative of indole-3-acetic acid, featuring dual trimethylsilyl (TMS) protecting groups. This compound is a crucial synthetic intermediate, prized for its role in facilitating complex organic transformations, particularly in the synthesis of advanced pharmaceutical agents and bioactive molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the protection and controlled functionalization of sensitive indole scaffolds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the research and development of new plant growth regulators and protective agents.
• Advanced Material Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and organic electronic materials.
• Academic & Industrial Research: Essential reagent for methodological studies in organic synthesis, particularly in silylation chemistry and heterocyclic compound manipulation.
• Peptide & Bioconjugate Chemistry: Employed for the temporary protection of carboxylic acid functionalities during multi-step synthetic sequences.

Basic Information

Product Name	1-Trimethylsilyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester
CAS No.	56114-66-0
Molecular Formula	C₁₆H₂₅NO₂Si₂
Molecular Weight	319.55 g/mol
Synonyms	Indole-3-acetic acid, 1-(trimethylsilyl)-, trimethylsilyl ester; 1-TMS-indole-3-acetic acid TMS ester; 1-(Trimethylsilyl)-1H-indole-3-acetic acid trimethylsilyl ester; 3-(Carboxymethyl)-1-(trimethylsilyl)-1H-indole trimethylsilyl ester; TMS-IAA-TMS; (1-Trimethylsilylindol-3-yl)acetic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Trimethylsilyl-1H-Indole-3-Acetic Acid Trimethylsilyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.