Description

(R)-N,n-Bis(Trimethylsilyl)-3,4,β-Tris[(Trimethylsilyl)Oxy]Benzeneethanamine CAS NO 56114-59-1 is a highly functionalized, chiral silylated amine derivative, specifically designed as a sophisticated building block and protecting group reagent in advanced organic synthesis. Its value lies in providing a sterically hindered, silicon-protected amine and phenolic hydroxyl groups, enabling selective deprotection strategies and complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs), chiral ligands, and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly those requiring protected amine and phenol functionalities.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Protecting Group Chemistry: The multiple trimethylsilyl (TMS) groups act as protective agents for amines and phenols, allowing for sequential and orthogonal deprotection in multi-step syntheses.
• Ligand and Catalyst Development: Used to construct novel chiral ligands for transition metal catalysis, such as in hydrogenation or cross-coupling reactions.
• Material Science Research: Potential monomer or functionalization agent for creating specialty silicon-containing polymers or surface-modified materials.
• Academic & R&D: A valuable tool for methodological development in organic chemistry laboratories focused on silicon chemistry and complex molecule assembly.

Basic Information

Product Name	(R)-N,n-Bis(Trimethylsilyl)-3,4,β-Tris[(Trimethylsilyl)Oxy]Benzeneethanamine
CAS No.	56114-59-1
Molecular Formula	C26H55NO3Si5
Molecular Weight	598.28 g/mol
Synonyms	(R)-N,N-Bis(trimethylsilyl)-3,4-bis((trimethylsilyl)oxy)phenethylamine; (R)-N,N-Bis(trimethylsilyl)-2-[3,4-bis(trimethylsiloxy)phenyl]ethanamine; (R)-TMS-protected Dopamine derivative; (R)-3,4-Bis(trimethylsiloxy)-N,N-bis(trimethylsilyl)phenethylamine; (R)-N,N-Bis(TMS)-3,4-bis(TMS-oxy)phenethylamine; (R)-2-(3,4-Bis(trimethylsiloxy)phenyl)-N,N-bis(trimethylsilyl)ethanamine
EINECS	Contact for details

Quality Control

Every batch of (R)-N,n-Bis(Trimethylsilyl)-3,4,β-Tris[(Trimethylsilyl)Oxy]Benzeneethanamine is manufactured and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and enantiomeric excess meet exacting standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.