Description

D-Atabrine Dihydrochloride is the dihydrochloride salt of the dextrorotatory enantiomer of the classic antimalarial compound quinacrine. This high-purity chiral building block is critical for research and development in medicinal chemistry and pharmacology, particularly for studying stereospecific biological activity. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on chiral synthesis and drug discovery programs.

Application

• Pharmaceutical Research & Development: Serves as a key chiral intermediate or reference standard in the synthesis and study of novel therapeutic agents.
• Medicinal Chemistry Studies: Used to investigate the structure-activity relationship (SAR) and enantioselective effects of quinacrine derivatives.
• Biochemical Research: Employed as a tool compound in enzymatic and receptor-binding assays due to its specific stereochemistry.
• Analytical Reference Standard: Functions as a high-purity standard for chromatographic methods (HPLC, LC-MS) in quality control and method development.
• Fine Chemical Synthesis: Acts as a specialized building block for the preparation of more complex, chirally pure molecules.

Basic Information

Product Name	D-Atabrine Dihydrochloride
CAS No.	56100-41-5
Molecular Formula	C23H30ClN3O · 2HCl
Molecular Weight	472.88 g/mol (as dihydrochloride salt)
Synonyms	(+)-Quinacrine Dihydrochloride; D-Quinacrine Dihydrochloride; Dextro-Quinacrine Dihydrochloride; (R)-Quinacrine Dihydrochloride; (+)-Mepacrine Dihydrochloride; D-Mepacrine Dihydrochloride; 6-Chloro-9-[(4-diethylamino-1-methylbutyl)amino]-2-methoxyacridine Dihydrochloride (D-form); SN 390 Dihydrochloride (D-form)
EINECS	Contact for details

Quality Control

Our D-Atabrine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% ee (enantiomeric excess)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.