Description

[[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxy]Acetic Acid Trimethylsilyl Ester is a specialized organosilicon-protected phosphonic acid derivative, serving as a critical synthetic intermediate and protecting group reagent. Its primary value lies in enabling complex organic transformations, particularly in the synthesis of sensitive or biologically active molecules where standard phosphonate chemistry is incompatible. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science, who require high-purity, reactive intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs, antiviral agents, and other bioactive molecules containing phosphonate or phosphate ester functionalities.
• Agrochemical Synthesis: Used in the production of advanced herbicides, plant growth regulators, and pesticides that incorporate phosphonic acid groups.
• Peptide & Protein Modification: Acts as a phosphorylating or functionalizing agent for modifying amino acid side chains, such as serine, threonine, or tyrosine, in peptide synthesis.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and flame-retardant materials.
• Chemical Biology Research: Utilized as a probe or tool compound for studying enzyme mechanisms, particularly those involving kinases, phosphatases, and ATP-binding proteins.
• Ligand Synthesis for Catalysis: Employed in the preparation of phosphonate-based ligands for metal-organic frameworks (MOFs) and homogeneous catalysis.

Basic Information

Product Name	[[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxy]Acetic Acid Trimethylsilyl Ester
CAS No.	56009-10-0
Molecular Formula	C11H29O6PSi3
Molecular Weight	364.57 g/mol
Synonyms	Acetic acid, [[bis[(trimethylsilyl)oxy]phosphinyl]oxy]-, trimethylsilyl ester; (Trimethylsilyloxy)acetic acid bis(trimethylsilyl) phosphate; Tris(trimethylsilyl) phosphonoacetate; TMS-PAA; Phosphonoacetic Acid Tris(trimethylsilyl) Ester; [[Bis(trimethylsiloxy)phosphoryl]oxy]acetic Acid Trimethylsilyl Ester; Acetic acid, 2-[[bis[(trimethylsilyl)oxy]phosphinyl]oxy]-, 1-(trimethylsilyl) ester
EINECS	Contact for details

Quality Control

Our production of [[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Oxy]Acetic Acid Trimethylsilyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including NMR, HPLC, and GC-MS, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (NMR)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.