Description

n-[2-[(Trimethylsilyl)Oxy]Benzoyl]Glycine Trimethylsilyl Ester is a specialized organosilicon-protected derivative of glycine, designed for advanced synthetic applications where moisture-sensitive intermediates are required. This compound matters as a critical building block in the synthesis of complex molecules, offering enhanced stability and reactivity control during peptide coupling and other sensitive chemical transformations. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key protected amino acid derivative in the multi-step synthesis of peptide-based drugs and complex organic molecules.
• Peptide Synthesis: Used as a building block in solid-phase and solution-phase peptide synthesis, where the trimethylsilyl (TMS) groups provide temporary protection for the carboxylic acid and hydroxyl functionalities.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and constructing molecular libraries.
• Fine Chemical Production: Acts as a precursor in the manufacture of high-value specialty chemicals, agrochemicals, and advanced materials.
• Protecting Group Chemistry: Utilized in reactions where selective protection and deprotection of functional groups are necessary to achieve desired synthetic outcomes.

Basic Information

Product Name	n-[2-[(Trimethylsilyl)Oxy]Benzoyl]Glycine Trimethylsilyl Ester
CAS No.	55887-56-4
Molecular Formula	C15H25NO4Si2
Molecular Weight	339.54 g/mol
Synonyms	Glycine, N-[2-[(trimethylsilyl)oxy]benzoyl]-, trimethylsilyl ester; N-(2-(Trimethylsilyloxy)benzoyl)glycine Trimethylsilyl Ester; 2-[(Trimethylsilyl)oxy]benzoic Acid Glycine Trimethylsilyl Ester Derivative; TMS-Protected Salicyloyl Glycine; Bis(trimethylsilyl) Ester of N-Salicyloylglycine
EINECS	Contact for details

Quality Control

Our n-[2-[(Trimethylsilyl)Oxy]Benzoyl]Glycine Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.