Description

2-Piperidinecarboxylic Acid Trimethylsilyl Ester is a protected derivative of pipecolic acid, a non-proteinogenic amino acid, where the carboxylic acid group is masked as a trimethylsilyl (TMS) ester. This protection is crucial for synthetic organic chemistry, as it enhances solubility in organic solvents and prevents unwanted side reactions during peptide synthesis or complex molecule construction. This high-purity intermediate is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, particularly those containing pipecolic acid or proline analogs.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to construct peptides with modified backbone structures.
• Chemical Research & Development: Serves as a versatile synthon in academic and industrial R&D for exploring new reaction pathways and creating libraries of novel compounds.
• Agrochemical Synthesis: Employed in the development of advanced pesticides and herbicides where specific chiral amino acid frameworks are required for bioactivity.
• Ligand and Catalyst Preparation: Useful for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	2-Piperidinecarboxylic Acid Trimethylsilyl Ester
CAS No.	55887-52-0
Molecular Formula	C9H19NO2Si
Molecular Weight	201.34 g/mol
Synonyms	Pipecolic Acid Trimethylsilyl Ester; (S)-(-)-Pipecolic Acid Trimethylsilyl Ester; L-Pipecolic Acid TMS Ester; Trimethylsilyl Pipecolate; 2-Carboxypiperidine Trimethylsilyl Ester; TMS-Pipecolic Acid; 1-((Trimethylsilyl)oxy)carbonylpiperidine-2-carboxylic Acid (tautomeric form)
EINECS	Contact for details

Quality Control

Every batch of 2-Piperidinecarboxylic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.