Description

4-[Acetyl(Trimethylsilyl)Amino]Phenyl 2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Trimethylsilyl Ester is a sophisticated, fully protected derivative of glucuronic acid, designed for advanced synthetic and analytical chemistry. This compound is critically important as a key intermediate or analytical standard in the synthesis of complex glycoconjugates and for metabolic studies. It is primarily needed by research institutions and pharmaceutical companies engaged in drug metabolism and pharmacokinetics (DMPK) research, prodrug development, and the synthesis of bioactive glycosides.

Application

• Drug Metabolism Research: Serves as a crucial intermediate or reference standard in the study of glucuronidation pathways, a major Phase II drug metabolism route.
• Synthetic Chemistry: Used as a protected building block for the synthesis of complex oligosaccharides, glycoconjugates, and targeted prodrugs.
• Analytical Standard: Employed as a high-purity standard in LC-MS, HPLC, and NMR for the identification and quantification of glucuronide metabolites.
• Bioconjugation: Acts as a derivatization agent or a protected precursor for attaching carbohydrate motifs to other molecules like proteins or small molecule drugs.
• Biochemical Tool Development: Utilized in the development of enzyme substrates or inhibitors for glycosyltransferases and related enzymes.

Basic Information

Product Name	4-[Acetyl(Trimethylsilyl)Amino]Phenyl 2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Trimethylsilyl Ester
CAS No.	55836-51-6
Molecular Formula	C₃₂H₅₉NO₁₀Si₅
Molecular Weight	778.28 g/mol
Synonyms	Per-TMS Glucuronide Derivative; 4-[Acetyl(trimethylsilyl)amino]phenyl 2,3,4-tri-O-trimethylsilyl-β-D-glucopyranosiduronic acid trimethylsilyl ester; Fully Silylated Glucuronic Acid Phenyl Derivative; β-D-Glucopyranosiduronic acid, 4-[acetyl(trimethylsilyl)amino]phenyl 2,3,4-tri-O-trimethylsilyl-, trimethylsilyl ester; TMS-Glucuronide Probe
EINECS	Contact for details

Quality Control

Our production of this high-value specialty chemical adheres to stringent quality protocols. Each batch undergoes comprehensive analysis using techniques including NMR, HPLC, and LC-MS to confirm structural identity and purity. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a desiccated environment to prevent moisture ingress and decomposition. Handle under an inert atmosphere (argon or nitrogen) for long-term storage stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.