Description

n-(2-Methyl-1-Oxopropyl)Glycine Trimethylsilyl Ester is a specialized organosilicon-protected amino acid derivative, serving as a crucial synthetic intermediate. Its primary value lies in enabling advanced peptide and organic synthesis by protecting the carboxylic acid functionality, thereby enhancing solubility and directing regioselective reactions. This high-purity building block is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science who require reliable, high-quality intermediates for complex molecular construction.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Peptide Chemistry: Protects glycine derivatives during solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Organic Synthesis: Acts as a masked carboxylic acid reagent in multi-step syntheses of complex organic molecules.
• Material Science Research: Employed in the development of functionalized polymers and silicon-containing hybrid materials.
• Chemical Biology Probes: Useful for creating labeled amino acid analogs for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	n-(2-Methyl-1-Oxopropyl)Glycine Trimethylsilyl Ester
CAS No.	55836-41-4
Molecular Formula	C9H19NO3Si
Molecular Weight	217.34 g/mol
Synonyms	N-(2-Methyl-1-oxopropyl)glycine trimethylsilyl ester; Trimethylsilyl N-(2-methylpropanoyl)glycinate; Glycine, N-(2-methyl-1-oxopropyl)-, trimethylsilyl ester; N-(2-Methylpropanoyl)glycine trimethylsilyl ester; TMS ester of N-isobutyrylglycine; N-Isobutyrylglycine TMS ester; (Trimethylsilyl) 2-[(2-methylpropanoyl)amino]acetate
EINECS	Contact for details

Quality Control

Our n-(2-Methyl-1-Oxopropyl)Glycine Trimethylsilyl Ester is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with customer requirements for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.