Description

n-(1-Oxopropyl)Glycine Trimethylsilyl Ester is a specialized organosilicon-protected amino acid derivative, serving as a crucial building block in advanced organic synthesis. This compound is valued for its role in facilitating complex peptide coupling and protecting group strategies, enabling the creation of novel molecular architectures. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key protected synthon for the synthesis of modified peptides, peptidomimetics, and novel drug candidates.
• Agrochemical Research: Used in constructing specialized amino acid-based components for new herbicides, fungicides, and plant growth regulators.
• Peptide Chemistry: Facilitates solid-phase and solution-phase peptide synthesis (SPPS) by providing a temporary trimethylsilyl (TMS) protecting group for the glycine carboxylate.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged amino acids for studying biological pathways and protein interactions.
• Material Science: Acts as a precursor for functionalized surfaces or polymers incorporating amino acid motifs.
• Process Development: Serves as a high-purity intermediate for scaling up the production of target molecules under controlled GMP-like conditions.

Basic Information

Product Name	n-(1-Oxopropyl)Glycine Trimethylsilyl Ester
CAS No.	55836-38-9
Molecular Formula	C8H17NO3Si
Molecular Weight	203.31 g/mol
Synonyms	N-(1-Oxopropyl)glycine trimethylsilyl ester; N-Propanoylglycine TMS ester; Glycine, N-(1-oxopropyl)-, trimethylsilyl ester; Trimethylsilyl N-propanoylglycinate; 2-[(Trimethylsilyl)oxycarbonylmethylamino]-1-propanone; TMS-N-propanoylglycinate
EINECS	Contact for details

Quality Control

Every batch of n-(1-Oxopropyl)Glycine Trimethylsilyl Ester is produced and tested under stringent quality management protocols to ensure consistency and purity for sensitive synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic analysis, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.