Description

n-Formylglycine Trimethylsilyl Ester is a protected derivative of formylglycine, a key intermediate in organic synthesis. This compound is valued for its role in introducing the formylglycine moiety under silyl-protected conditions, enabling complex peptide and glycopeptide synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel bioactive molecules and chemical probes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex peptide-based drugs and therapeutic agents.
• Proteomics Research: Used in the study of post-translational modifications and the synthesis of modified amino acids for biochemical assays.
• Glycopeptide Synthesis: Serves as a protected precursor for incorporating formylglycine residues into glycopeptide structures.
• Chemical Biology: Employed in the development of activity-based probes and inhibitors targeting sulfatases and related enzymes.
• Organic Synthesis: Acts as a specialized reagent for introducing protected amino acid functionalities in multi-step synthetic routes.

Basic Information

Product Name	n-Formylglycine Trimethylsilyl Ester
CAS No.	55836-37-8
Molecular Formula	C6H13NO3Si
Molecular Weight	175.26 g/mol
Synonyms	N-Formylglycine Trimethylsilyl Ester; Trimethylsilyl N-Formylglycinate; (Trimethylsilyl) 2-Formamidoacetate; 2-Formamidoacetic Acid Trimethylsilyl Ester; Formylglycine TMS Ester; FGly-OTMS; N-Formylglycine O-Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our n-Formylglycine Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.