Description

[(5Z,7E)-9,10-Secocholesta-5,7,10(19)-Triene-1,3β,25-Triyl]Tris(Oxy)]Tris(Trimethylsilane) CAS NO 55759-95-0 is a high-purity, protected derivative of a key vitamin D intermediate. This compound is critical for ensuring the stability and reactivity of the active moiety during complex synthetic pathways, particularly in multi-step pharmaceutical manufacturing. It is primarily required by research institutions and pharmaceutical companies engaged in the development and production of advanced vitamin D analogs and related steroidal therapeutics.

Application

• Key Synthetic Intermediate for the production of calcitriol, tacalcitol, and other vitamin D receptor modulators.
• Advanced Pharmaceutical Research (API development) for osteoporosis, psoriasis, and cancer treatment candidates.
• Process Chemistry where the trimethylsilyl (TMS) protecting groups are essential for selective reactions.
• Reference Standard for analytical method development and quality control in steroid chemistry.
• Custom Synthesis of novel seco-steroid derivatives for biological evaluation.
• Chemical Building Block in academic and industrial research exploring steroidal frameworks.

Basic Information

Product Name	[(5Z,7E)-9,10-Secocholesta-5,7,10(19)-Triene-1,3β,25-Triyl]Tris(Oxy)]Tris(Trimethylsilane)
CAS No.	55759-95-0
Molecular Formula	C36H68O3Si3
Molecular Weight	633.2 g/mol
Synonyms	1,3-Bis-O-(trimethylsilyl)-25-O-(trimethylsilyl)-9,10-secocholesta-5,7,10(19)-triene; (1α,3β,5Z,7E)-1,3,25-Tris[(trimethylsilyl)oxy]-9,10-secocholesta-5,7,10(19)-triene; TMS-protected Vitamin D3 intermediate; 1,3,25-Tris-O-TMS-cholestatriene; Tris(trimethylsilyl) ether of 1,3,25-trihydroxy-9,10-secocholesta-5,7,10(19)-triene
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and GC. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.