Description

5-o-Trityl-2,3-o-Isopropylidene-D-Ribofuranose is a key protected ribofuranose derivative, serving as a critical chiral building block in organic synthesis. Its value lies in providing a versatile scaffold for the controlled introduction of nucleoside analogs and other complex sugar-based molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of antiviral and anticancer therapeutics.

Application

• Nucleoside and Nucleotide Synthesis: A fundamental precursor for constructing modified nucleosides used in antiviral (e.g., HCV, HIV) and anticancer drug candidates.
• Oligonucleotide Chemistry: Used in the preparation of protected phosphoramidite monomers for solid-phase synthesis of oligonucleotides and antisense agents.
• Carbohydrate Chemistry: Serves as a chiral starting material for the synthesis of complex carbohydrates, glycoconjugates, and glycomimetics.
• Pharmaceutical Intermediates: A critical building block in multi-step synthetic routes for active pharmaceutical ingredients (APIs) targeting various diseases.
• Biochemical Research: Employed in academic and industrial R&D for studying enzyme mechanisms, metabolic pathways, and as a probe in chemical biology.
• Labeled Compound Preparation: Useful for introducing isotopic labels (e.g., 13C, 2H) into sugar moieties for metabolic tracing and pharmacokinetic studies.

Basic Information

Product Name	5-o-Trityl-2,3-o-Isopropylidene-D-Ribofuranose
CAS No.	55726-19-7
Molecular Formula	C29H30O5
Molecular Weight	458.55 g/mol
Synonyms	1,2-O-Isopropylidene-5-O-trityl-α-D-ribofuranose; 5-O-Trityl-1,2-O-isopropylidene-α-D-ribofuranose; 5-O-Triphenylmethyl-2,3-O-isopropylidene-D-ribofuranose; D-Ribofuranose, 5-O-trityl-2,3-O-isopropylidene-; 1,2-O-(1-Methylethylidene)-5-O-triphenylmethyl-α-D-ribofuranose; 5-O-Trityl-2,3-O-isopropylidene-D-ribose; Protected D-Ribofuranose Derivative
EINECS	Contact for details

Quality Control

Our 5-o-Trityl-2,3-o-Isopropylidene-D-Ribofuranose is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.