Description

n-(Trimethylsilyl)Benzeneacetamide is a specialized organosilicon reagent featuring a trimethylsilyl (TMS) protecting group on the amide nitrogen. This compound is valued for its role as a key synthetic intermediate in advanced organic and medicinal chemistry, where it facilitates the controlled introduction of the phenylacetamide moiety. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive amide functionality.
• Peptide Mimetics & Modifications: Serves as a protected amide synthon for constructing peptide analogs and modifying peptide backbones in drug discovery.
• Material Science Research: Employed as a precursor or modifying agent in the development of specialty polymers and silicon-containing advanced materials.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, particularly in reactions involving silyl protecting group strategies.

Basic Information

Product Name	n-(Trimethylsilyl)Benzeneacetamide
CAS No.	55724-32-8
Molecular Formula	C11H17NOSi
Molecular Weight	207.35 g/mol
Synonyms	N-(Trimethylsilyl)-2-phenylacetamide; Benzeneacetamide, N-(trimethylsilyl)-; Phenylacetamide, N-(trimethylsilyl)-; α-Toluanilide, N-(trimethylsilyl)-; TMS-Phenylacetamide; N-TMS-Phenylacetamide; (Trimethylsilyl)phenylacetamide; N-(Trimethylsilyl)phenylacetamide
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)Benzeneacetamide is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming the product meets the agreed specifications for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.