Description

(1R)-2β-(3-Methoxy-3-Oxopropyl)-3β,5α-Bis(Trimethylsilyloxy)-ε-Oxocyclopentaneoctanoic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex, functionalized cyclopentane core. This compound is of critical importance for its role as a key synthetic precursor in the production of prostaglandin analogs and other bioactive molecules. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in the fields of ophthalmology and cardiovascular medicine.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of prostaglandin-based active pharmaceutical ingredients (APIs).
• Prostaglandin Analog Synthesis: Specifically used in the production of latanoprost, bimatoprost, travoprost, and related compounds used to treat glaucoma and ocular hypertension.
• Organic Synthesis Research: Serves as a versatile chiral template for medicinal chemists exploring new chemical entities with cyclopentane or prostaglandin-like structures.
• Process Development & Scale-Up: Employed in pilot plants and commercial manufacturing for optimizing synthetic routes to prostaglandin drugs.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in API production.

Basic Information

Product Name	(1R)-2β-(3-Methoxy-3-Oxopropyl)-3β,5α-Bis(Trimethylsilyloxy)-ε-Oxocyclopentaneoctanoic Acid Methyl Ester
CAS No.	55670-02-5
Molecular Formula	C26H48O7Si2
Molecular Weight	528.83 g/mol
Synonyms	(1R,2R,3R,5S)-3,5-Bis[(trimethylsilyl)oxy]-2-[(3RS)-3-methoxy-3-oxopropyl]cyclopentyl]heptanoic acid methyl ester; Corey Lactone Diol TMS Ether; 3,5-Bis-O-(trimethylsilyl)-11,15-O-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid methyl ester (protected form); Prostaglandin F2α TMS Derivative; Latanoprost Intermediate; Bimatoprost Key Intermediate; Travoprost Synthetic Precursor; 9-Oxo-11α,15α-bis(trimethylsiloxy)-5-cis,13-trans-prostadienoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict cGMP guidelines where applicable, ensuring traceability and consistency for pharmaceutical use. Every batch undergoes comprehensive analytical characterization including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with each shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas (e.g., nitrogen or argon) when opening the container to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.