Description

Difluoro(4-Nitrophenyl)Methyl Isocyanate is a specialized aromatic isocyanate derivative featuring both nitro and difluoromethyl substituents. This compound is valued for its high reactivity as an isocyanate building block, enabling the synthesis of ureas, carbamates, and other functional materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the bioactivity of the difluoromethyl and nitroaryl motifs.
• Polymer Modification: Serves as a functional monomer or cross-linking agent for introducing urethane linkages into specialty polymers, enhancing material properties.
• Chemical Biology Probes: Employed in the creation of activity-based probes (ABPs) and other research tools for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Material Science Research: Investigated for incorporation into advanced organic frameworks, coatings, or adhesives where specific chemical resistance or surface properties are required.

Basic Information

Product Name	Difluoro(4-Nitrophenyl)Methyl Isocyanate
CAS No.	55669-96-0
Molecular Formula	C8H4F2N2O3
Molecular Weight	214.13 g/mol
Synonyms	1-Isocyanato-2,2-difluoro-1-(4-nitrophenyl)ethane; 2,2-Difluoro-1-(4-nitrophenyl)ethyl isocyanate; (2,2-Difluoro-1-(4-nitrophenyl)ethyl) isocyanate; 4-Nitro-α,α-difluorobenzyl isocyanate; Difluoro(p-nitrophenyl)methyl isocyanate; α,α-Difluoro-4-nitrobenzyl isocyanate
EINECS	Contact for details

Quality Control

Our Difluoro(4-Nitrophenyl)Methyl Isocyanate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and process chemistry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.