Description

Nimustine Hydrochloride CAS NO 55661-38-6 is a nitrosourea-based alkylating agent, a critical pharmaceutical active ingredient (API) used in oncology. This compound is valued for its potent antitumor activity, primarily functioning by cross-linking DNA strands to inhibit cancer cell proliferation. It is essential for pharmaceutical manufacturers and research institutions developing chemotherapeutic formulations, particularly for treating brain tumors and other malignancies.

Application

• Primary Active Pharmaceutical Ingredient (API) in injectable chemotherapeutic drugs.
• Key intermediate in the synthesis of advanced, targeted oncology medications.
• Research chemical for in vitro and in vivo studies on glioblastoma and other central nervous system (CNS) tumors.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Component in combination therapy research protocols for enhanced cancer treatment efficacy.
• Starting material for the preparation of novel nitrosourea derivatives in medicinal chemistry.

Basic Information

Product Name	Nimustine Hydrochloride
CAS No.	55661-38-6
Molecular Formula	C₉H₁₃ClN₆O₂ • HCl
Molecular Weight	309.15 g/mol
Synonyms	ACNU; Nidran; 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride; Nitrumon; Nimustine HCl; 1-(2-Chloroethyl)-3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-nitrosourea hydrochloride
EINECS	Contact for details

Quality Control

Our Nimustine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA), confirming identity, purity, and impurity profiles via methods such as HPLC, is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.