Description

n-(3-Methyl-1-Oxo-2-Butenyl)-n-(Trimethylsilyl)Glycine Trimethylsilyl Ester is a specialized organosilicon-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a dual-protected glycine moiety, where both the amine and carboxyl groups are shielded by trimethylsilyl groups, enabling selective deprotection and controlled reactivity. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and materials science who require high-purity, moisture-sensitive intermediates for constructing complex peptide mimetics and active molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel peptide-based drugs, protease inhibitors, and other bioactive molecules requiring protected amino acid motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators where the glycine backbone is incorporated into the active ingredient.
• Peptidomimetics Research: Enables the construction of non-natural peptide analogs and constrained structures for drug discovery and biochemical studies.
• Organometallic & Catalysis: Serves as a ligand precursor or a modifying agent in the development of asymmetric catalysts and metal-organic frameworks (MOFs).
• Specialty Polymer Modification: Used to introduce functional, silyl-protected amino groups into polymer chains for creating smart materials and biocompatible coatings.
• Chemical Biology Probes: Facilitates the synthesis of labeled amino acids and activity-based probes for studying enzyme mechanisms and protein interactions.

Basic Information

Product Name	n-(3-Methyl-1-Oxo-2-Butenyl)-n-(Trimethylsilyl)Glycine Trimethylsilyl Ester
CAS No.	55649-86-0
Molecular Formula	C13H27NO3Si2
Molecular Weight	301.53 g/mol
Synonyms	N-(3-Methyl-1-oxo-2-buten-1-yl)-N-(trimethylsilyl)glycine trimethylsilyl ester; Glycine, N-(3-methyl-1-oxo-2-butenyl)-N-(trimethylsilyl)-, trimethylsilyl ester; N-(Trimethylsilyl)-N-(3-methyl-1-oxo-2-butenyl)glycine trimethylsilyl ester; TMS-Glycine derivative; Dual-TMS protected glycine enamine ester; 3-Methyl-1-oxo-2-butenyl TMS glycine TMS ester
EINECS	Contact for details

Quality Control

Our n-(3-Methyl-1-Oxo-2-Butenyl)-n-(Trimethylsilyl)Glycine Trimethylsilyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing exact specifications and test results. Our commitment to quality supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Store away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.