Description

3-Methylene-1,2-Cyclopropanedicarboxylic Acid Diethyl Ester is a specialized diester derivative of a cyclopropane carboxylic acid, serving as a versatile and reactive synthetic intermediate. Its unique strained-ring structure and activated methylene group make it a valuable building block for constructing complex molecular frameworks in advanced organic synthesis. This compound is particularly relevant for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce cyclopropane motifs or functionalized ester groups into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing cyclopropane rings known for metabolic stability and conformational restriction.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides where the cyclopropane unit can enhance biological activity.
• Material Science Monomer: Used in polymer research for developing specialty polymers with unique thermal or mechanical properties derived from the strained ring system.
• Organic Synthesis Reagent: Employed in Diels-Alder reactions, [2+1] cycloadditions, and other cyclization strategies to construct complex carbocyclic and heterocyclic compounds.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing chiral ligands or organocatalysts used in asymmetric synthesis.
• Flavor & Fragrance Industry: Intermediate for the production of certain ester-based aroma chemicals.

Basic Information

Product Name	3-Methylene-1,2-Cyclopropanedicarboxylic Acid Diethyl Ester
CAS No.	55638-55-6
Molecular Formula	C11H16O4
Molecular Weight	212.24 g/mol
Synonyms	Diethyl 3-Methylene-1,2-cyclopropanedicarboxylate; 1,2-Cyclopropanedicarboxylic Acid, 3-Methylene-, Diethyl Ester; 3-Methyleneciclopropano-1,2-dicarbossilato di etile; Diethyl 3-methyleneciclopropane-1,2-dicarboxylate; NSC 334044; Ethyl 3-methylene-1,2-cyclopropanedicarboxylate; 3-Methylenecyclopropane-1,2-dicarboxylic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our 3-Methylene-1,2-Cyclopropanedicarboxylic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.