Description

3-O,4-o-Bis(Trimethylsilyl)-D-Erythro-2-Pentulose 1,5-Bis[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly specialized, multi-silylated carbohydrate derivative that serves as a critical protected intermediate in advanced organic synthesis. This compound is valued for its role in facilitating complex chemical transformations where precise control over hydroxyl group reactivity is paramount. It is primarily sought by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of nucleoside analogs, complex sugars, and other bioactive molecules.

Application

• Key Intermediate in Nucleoside/Nucleotide Synthesis: Used in the preparation of protected sugar phosphates for antiviral and anticancer drug candidates.
• Building Block for Carbohydrate Chemistry: Enables the stereoselective construction of complex oligosaccharides and glycomimetics.
• Phosphorylation Agent in Sensitive Syntheses: Acts as a protected phosphate donor in reactions where standard phosphorylation methods are incompatible.
• Research & Development of Prodrugs: Employed in the design and synthesis of phosphate-based prodrugs to enhance drug delivery and bioavailability.
• Synthesis of Labeled Compounds: Useful for incorporating stable isotopes (e.g., 13C, 15N) into sugar-phosphate backbones for metabolic studies.
• Process Chemistry Development: Serves as a high-purity starting material for scaling up synthetic routes to active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	3-O,4-o-Bis(Trimethylsilyl)-D-Erythro-2-Pentulose 1,5-Bis[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	55622-57-6
Molecular Formula	C23H58O8P2Si6
Molecular Weight	Approx. 689.2 g/mol
Synonyms	1,5-Bis[bis(trimethylsilyl)phosphoryl]-3,4-bis-O-(trimethylsilyl)-D-erythro-pent-2-ulose; D-Erythro-Pentulose, 3,4-bis-O-(trimethylsilyl)-, 1,5-bis[bis(trimethylsilyl) phosphate]; Protected D-Erythro-2-Pentulose Bisphosphate; TMS-Protected Pentulose Bisphosphate Ester; Silylated Carbohydrate Phosphate Intermediate; CAS 55622-57-6
EINECS	Contact for details

Quality Control

Every batch of 3-O,4-o-Bis(Trimethylsilyl)-D-Erythro-2-Pentulose 1,5-Bis[Phosphoric Acid Bis(Trimethylsilyl)] Ester is manufactured and tested under strict quality management systems to ensure consistency and reliability for critical research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR conformation, and identity verification (IR). A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions, preferably in a glovebox or under an inert atmosphere (argon/nitrogen) to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.