Description

4-(Acetylamino)Phenyl 2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Methyl Ester is a sophisticated, fully protected derivative of a glucuronic acid conjugate, designed for advanced synthetic and analytical chemistry. This compound is of significant value as a key synthetic intermediate or analytical standard in the development of complex carbohydrate-based molecules and drug metabolites. It is primarily required by research institutions and pharmaceutical companies engaged in glycochemistry, prodrug development, and metabolic pathway studies, where precise chemical manipulation is critical.

Application

• Pharmaceutical Intermediate: Serves as a protected precursor in the synthesis of glucuronide metabolites for pharmacokinetic and drug metabolism studies.
• Glycoconjugate Research: Used in the chemical synthesis of complex oligosaccharides and glycoconjugates for biological activity screening.
• Analytical Standard: Acts as a high-purity reference standard for HPLC, LC-MS, or NMR analysis in method development and validation.
• Prodrug Development: Employed in the design and synthesis of prodrugs that utilize glucuronidation as an activation or detoxification mechanism.
• Biochemical Tool: Utilized in enzymatic studies to investigate the activity of glucuronosyltransferases (UGTs) and other related enzymes.
• Chemical Biology Probe: Functions as a building block for creating labeled or tagged carbohydrate probes to study biological recognition events.

Basic Information

Product Name	4-(Acetylamino)Phenyl 2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Methyl Ester
CAS No.	55591-02-1
Molecular Formula	C24H43NO9Si3
Molecular Weight	585.9 g/mol
Synonyms	Methyl (2,3,4-tri-O-trimethylsilyl-β-D-glucopyranosyluronate) 1-(4-acetamidophenyl); 4-Acetamidophenyl 2,3,4-tri-O-trimethylsilyl-β-D-glucopyranosiduronic acid methyl ester; TMS-protected glucuronide methyl ester; 4-Acetamidophenyl glucuronide TMS methyl ester; Per-TMS glucuronide derivative; N-Acetyl-4-aminophenyl β-D-glucopyranosiduronic acid methyl ester tris(trimethylsilyl) ether; Glucuronic acid conjugate, TMS protected methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 4-(Acetylamino)Phenyl 2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Methyl Ester is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing specific results for each parameter are available upon request, supporting your research and development with full traceability and data integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. Long-term storage under inert atmosphere (argon or nitrogen) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.