Description

2-Methoxy-α-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester is a specialized organosilicon reagent and a key protected intermediate in synthetic organic chemistry. Its value lies in its role as a versatile synthon for introducing the 2-methoxyphenylacetic acid moiety under mild conditions, crucial for constructing complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs) containing arylacetic acid derivatives.
• Agrochemical Synthesis: Used in the production of herbicides and plant growth regulators that require the incorporation of a methoxyphenylacetic acid structure.
• Peptide Mimetics & Prodrug Development: Serves as a protected carboxylic acid derivative for creating peptide analogs and designing prodrugs with enhanced bioavailability.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Research: Acts as a monomer or functionalization agent in the development of novel polymers and advanced organic materials.
• Academic & Contract Research: Essential reagent for methodological development and complex multi-step synthesis in academic and industrial research laboratories.

Basic Information

Product Name	2-Methoxy-α-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester
CAS No.	55590-94-8
Molecular Formula	C13H20O4Si
Molecular Weight	268.38 g/mol
Synonyms	Methyl 2-Methoxy-α-(trimethylsiloxy)benzeneacetate; Methyl (2-Methoxyphenyl)(trimethylsilyloxy)acetate; 2-Methoxyphenyl(trimethylsilyloxy)acetic Acid Methyl Ester; O-Methyl Mandelic Acid Trimethylsilyl Ether Methyl Ester (2-Methoxy derivative); (2-Methoxyphenyl)(trimethylsiloxy)acetic Acid Methyl Ester; α-(Trimethylsiloxy)-2-methoxybenzeneacetic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of 2-Methoxy-α-(Trimethylsiloxy)Benzeneacetic Acid Methyl Ester is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP-compliant applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture ingress and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.