Description

2-C-Methyl-2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Ribonic Acid γ-Lactone CAS NO 55570-77-9 is a key protected ribose derivative, serving as a sophisticated chiral building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex nucleoside analogs and other bioactive molecules. This high-purity intermediate is essential for pharmaceutical R&D and fine chemical manufacturers focused on antiviral, anticancer, and other therapeutic agents.

Application

• Nucleoside & Nucleotide Synthesis: A critical protected intermediate for the synthesis of modified ribonucleosides and their phosphate analogs.
• Antiviral Drug Development: Used in the research and production of novel antiviral compounds, particularly those targeting RNA viruses.
• Pharmaceutical Intermediates: Serves as a chiral precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Carbohydrate Chemistry: Employed in the study and synthesis of complex sugars and glycomimetics with specific stereochemistry.
• Labeled Compound Synthesis: Useful for preparing isotopically labeled (e.g., 13C, 2H) versions of nucleosides for metabolic and pharmacokinetic studies.
• Bioconjugation & Probe Development: Acts as a starting material for creating chemical probes used in biochemical and diagnostic applications.

Basic Information

Product Name	2-C-Methyl-2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Ribonic Acid γ-Lactone
CAS No.	55570-77-9
Molecular Formula	C15H34O5Si3
Molecular Weight	390.68 g/mol
Synonyms	2-C-Methyl-2,3,5-O-tris(trimethylsilyl)-D-ribono-1,4-lactone; 2-C-Methyl-D-ribono-1,4-lactone 2,3,5-tris(trimethylsilyl) ether; 2-C-Methyl-2,3,5-tris-O-(trimethylsilyl)-D-ribonic acid γ-lactone; 2-C-Methyl-D-ribono-γ-lactone 2,3,5-tris-O-TMS ether; Protected 2-C-Methyl-D-ribonolactone; TMS-protected 2-C-methylribonolactone; 2-C-Methyl-2,3,5-tris-O-(TMS)-D-ribono-1,4-lactone
EINECS	Contact for details

Quality Control

Our 2-C-Methyl-2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Ribonic Acid γ-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.