Description

β-D-Glucopyranosiduronic Acid, 3-(5-Ethylhexahydro-2,4,6-Trioxo-5-P Yrimidinyl)-1,1-Dimethylpropyl 2,3,4-Tris-o-(Trimethylsilyl)-, Methyl Ester is a complex, highly functionalized chemical intermediate featuring a glucuronic acid core modified with protective trimethylsilyl (TMS) groups and a barbiturate-derived moiety. This compound is of significant value for advanced synthetic chemistry, particularly in the development of novel pharmaceuticals and bioactive molecules where precise glycosylation and controlled deprotection are required. It is primarily utilized by research institutions and industrial R&D departments specializing in medicinal chemistry, carbohydrate chemistry, and the synthesis of prodrugs or targeted therapeutic agents.

Application

• Advanced Pharmaceutical Intermediates: Serves as a key building block in the synthesis of complex drug candidates, especially those requiring glucuronidation for metabolic studies or prodrug activation.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting enzymes or receptors that interact with glucuronic acid derivatives.
• Carbohydrate Chemistry: Acts as a protected glucuronic acid donor in glycosylation reactions for the synthesis of oligosaccharides, glycoconjugates, and other biologically active carbohydrates.
• Bioconjugation & Probe Development: Utilized in the creation of chemical probes, diagnostic agents, or antibody-drug conjugates (ADCs) where a cleavable glucuronide linker is advantageous.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for high-value fine chemicals and active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and the biological roles of glycosylated compounds.

Basic Information

Product Name	β-D-Glucopyranosiduronic Acid, 3-(5-Ethylhexahydro-2,4,6-Trioxo-5-Pyrimidinyl)-1,1-Dimethylpropyl 2,3,4-Tris-o-(Trimethylsilyl)-, Methyl Ester
CAS No.	55556-80-4
Molecular Formula	C27H52N2O11Si3
Molecular Weight	661.0 g/mol (approx.)
Synonyms	Methyl (2,3,4-Tris-O-trimethylsilyl-β-D-glucopyranosid)uronate 3-(5-ethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-1,1-dimethylpropyl ester; 1,1-Dimethyl-3-(5-ethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)propyl 2,3,4-tris-O-(trimethylsilyl)-β-D-glucopyranosiduronic acid methyl ester; TMS-protected Glucuronic Acid Barbiturate Ester; β-D-Glucopyranosiduronic acid, methyl ester, 3-(5-ethylhexahydro-2,4,6-trioxo-5-pyrimidinyl)-1,1-dimethylpropyl 2,3,4-tris-O-(trimethylsilyl)-; CAS 55556-80-4
EINECS	Contact for details

Quality Control

Every batch of this advanced chemical intermediate is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure consistency and reliability for your critical research and development work. Our quality systems are designed to support cGMP and ISO standards where required, ensuring traceability and compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.