Description

(2S)-5,7-Dichloro-2',4,6-Trimethoxy-6'β-Methylspiro[Benzofuran-2(3H),1'-[2]Cyclohexene]-3,4'-Dione is a complex, high-purity spirocyclic organic compound characterized by its unique fused ring system and specific stereochemistry. This compound is a critical advanced pharmaceutical intermediate and a valuable scaffold in medicinal chemistry research for developing novel therapeutic agents. It is primarily sought by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of complex molecules for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-infective drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for generating focused libraries of compounds in structure-activity relationship (SAR) studies to optimize biological activity and selectivity.
• Process Chemistry Development: Employed in route scouting and optimization studies for the efficient, scalable production of target drug molecules in both academic and industrial settings.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways or protein functions due to its complex, drug-like structure.
• Asymmetric Synthesis: Acts as a chiral starting material or template for synthesizing other enantiomerically pure compounds, leveraging its defined (2S) stereocenter.

Basic Information

Product Name	(2S)-5,7-Dichloro-2',4,6-Trimethoxy-6'β-Methylspiro[Benzofuran-2(3H),1'-[2]Cyclohexene]-3,4'-Dione
CAS No.	55555-63-0
Molecular Formula	C20H20Cl2O7
Molecular Weight	443.28 g/mol
Synonyms	(2S)-5,7-Dichloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione; 6'-Methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 5,7-dichloro-2',4,6-trimethoxy-, (2S)-; Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 5,7-dichloro-2',4,6-trimethoxy-6'-methyl-, (2S)-; (S)-5,7-Dichloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione; CAS 55555-63-0
EINECS	Contact for details

Quality Control

Our (2S)-5,7-Dichloro-2',4,6-Trimethoxy-6'β-Methylspiro[Benzofuran-2(3H),1'-[2]Cyclohexene]-3,4'-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.