Description

2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Galactopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly functionalized, silyl-protected carbohydrate derivative that serves as a critical synthetic intermediate. Its value lies in providing a reactive, protected galactose scaffold for the precise construction of complex glycoconjugates and nucleoside analogs. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for antiviral and anticancer drug discovery, as well as in advanced carbohydrate chemistry for creating labeled probes and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Glycoconjugate Synthesis: Used in the preparation of complex oligosaccharides, glycopeptides, and glycolipids for biological studies and drug development.
• Protecting Group Strategy: The tetrakis(trimethylsilyl) groups allow for selective deprotection and further functionalization at specific hydroxyl positions on the galactose ring.
• Labeled Sugar Precursor: Serves as a starting material for introducing isotopic labels (e.g., 13C, 2H) into sugar moieties for metabolic tracing and NMR studies.
• Chemical Biology Probes: Utilized in the creation of activity-based probes or inhibitors targeting carbohydrate-processing enzymes.
• Material Science: Potential precursor for synthesizing functionalized surfaces or polymers with carbohydrate motifs for biosensing applications.

Basic Information

Product Name	2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Galactopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	55530-81-9
Molecular Formula	C22H55O9PSi6
Molecular Weight	662.21 g/mol
Synonyms	α-D-Galactopyranose, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, cyclic phosphite (6:1) with phosphorous acid; Galactose cyclic phosphite hexa-TMS derivative; 1,2,3,4,6-Penta-O-trimethylsilyl-α-D-galactopyranose cyclic methylphosphonite; Hexakis(trimethylsilyl) α-D-galactopyranosyl phosphite; TMS-Galactose phosphite ester; Protected galactosyl phosphoramidite precursor; α-D-Galactopyranose, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, 1-(hydrogen methylphosphonite)
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Galactopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and cGMP-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. For long-term storage, consider storing under inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.