Description

2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Glucuronic Acid Trimethylsilyl Ester is a fully protected derivative of D-glucuronic acid, a key carbohydrate building block, designed for advanced synthetic chemistry. This compound is critically important as a protected intermediate that enables precise, multi-step organic synthesis by safeguarding reactive hydroxyl and carboxylic acid groups. It is primarily required by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex glycosides, prodrugs, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of glucuronide prodrugs, targeted drug conjugates, and metabolites.
• Glycochemistry Research: Used in the preparation of complex oligosaccharides, glycoconjugates, and glycomimetics for biological studies.
• Analytical Reference Standard: Serves as a high-purity standard for method development and quality control in carbohydrate analysis (e.g., HPLC, GC-MS).
• Agrochemical Synthesis: Intermediate in the development of novel, sugar-based pesticides and plant growth regulators.
• Fine Chemical Production: Enables the synthesis of specialty surfactants, chiral ligands, and other value-added chemical products.
• Process Chemistry: Facilitates scalable, efficient synthesis routes in GMP and non-GMP manufacturing environments.

Basic Information

Product Name	2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Glucuronic Acid Trimethylsilyl Ester
CAS No.	55530-80-8
Molecular Formula	C22H52O7Si5
Molecular Weight	581.13 g/mol
Synonyms	D-Glucuronic acid, 2,3,4,5-tetrakis-O-(trimethylsilyl)-, trimethylsilyl ester; Per-O-trimethylsilyl-D-glucuronic acid trimethylsilyl ester; TMS-D-Glucuronic Acid Ester (fully protected); 2,3,4,5-Tetra-O-trimethylsilyl-D-glucuronic acid trimethylsilyl ester; Fully silylated D-glucuronic acid; Glucuronic acid pentakis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Glucuronic Acid Trimethylsilyl Ester is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in GMP and research-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.