Description

2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-6-o-[Bis(Trimethylsilyloxy)Phosphinyl]-D-Glucose o-Methyl Oxime is a highly functionalized, silyl-protected carbohydrate derivative with a phosphinyl group. This compound is a critical advanced synthetic intermediate for the preparation of complex nucleoside analogs, modified sugars, and other bioactive molecules. It is primarily required by pharmaceutical R&D and fine chemical synthesis laboratories for building sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Carbohydrate Chemistry: Used in the preparation of complex, selectively protected sugar derivatives for glycobiology research.
• Oligonucleotide Synthesis: Serves as a phosphitylation reagent or modified sugar precursor for antisense and siRNA therapeutic development.
• Chemical Biology Probes: Enables the creation of labeled or tagged sugar molecules for studying metabolic pathways and enzyme functions.
• Fine Chemical Synthesis: Intermediate for producing specialty chemicals requiring precise stereochemistry and functional group manipulation.
• Academic & Industrial Research: Essential for exploratory chemistry in medicinal chemistry and synthetic methodology development.

Basic Information

Product Name	2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-6-o-[Bis(Trimethylsilyloxy)Phosphinyl]-D-Glucose o-Methyl Oxime
CAS No.	55530-73-9
Molecular Formula	C24H61NO9PSi6
Molecular Weight	708.31 g/mol
Synonyms	D-Glucose, O-methyloxime, 2,3,4,5-tetrakis-O-(trimethylsilyl)-6-[bis(trimethylsiloxy)phosphinyl]-; 6-O-[Bis(trimethylsiloxy)phosphinyl]-2,3,4,5-tetrakis-O-(trimethylsilyl)-D-glucose O-methyloxime; Tetrakis(trimethylsilyl) Glucose Methyl Oxime Phosphinyl Derivative; TMS-Glucose Phosphinyl Oxime; 55530-73-9; Hexakis(trimethylsilyl) Glucose Phosphonate Oxime
EINECS	Contact for details

Quality Control

Our production of this high-purity synthetic intermediate follows stringent in-process controls to ensure batch-to-batch consistency and structural integrity. Every lot is characterized by advanced analytical techniques including NMR (¹H, ¹³C, ³¹P) and HPLC to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.