Description

1,3-Bis(Trimethylsilyl)-2,6-Dioxo-1,2,3,6-Tetrahydro-4-Pyrimidinecarboxylic Acid Trimethylsilyl Ester is a highly functionalized, multi-silylated pyrimidine derivative that serves as a versatile and protected synthetic intermediate. This compound is valued for its role in facilitating complex organic transformations, particularly in the synthesis of nucleoside analogs and heterocyclic pharmaceuticals, by offering enhanced solubility and stability. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside and pyrimidine-based active pharmaceutical ingredients (APIs), including potential antiviral and anticancer agents.
• Agrochemical Research: Used in the development of new herbicides and fungicides that target specific biological pathways in plants.
• Organosilicon Chemistry: Acts as a valuable reagent for introducing trimethylsilyl protecting groups in multi-step synthetic routes, improving reaction yields and selectivity.
• Material Science Precursor: Potential monomer or cross-linking agent in the development of specialty silicon-containing polymers and advanced organic frameworks.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of high-value fine chemicals.
• Academic & R&D: Serves as a critical tool in medicinal chemistry and organic synthesis research for exploring new reaction methodologies and compound libraries.

Basic Information

Product Name	1,3-Bis(Trimethylsilyl)-2,6-Dioxo-1,2,3,6-Tetrahydro-4-Pyrimidinecarboxylic Acid Trimethylsilyl Ester
CAS No.	55530-63-7
Molecular Formula	C15H30N2O4Si3
Molecular Weight	386.66 g/mol
Synonyms	4-(Trimethylsiloxy)-2,6-dioxo-1,3-bis(trimethylsilyl)-1,2,3,6-tetrahydropyrimidine-5-carboxylic acid trimethylsilyl ester; 1,3-Bis(trimethylsilyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid trimethylsilyl ester; Trimethylsilyl 1,3-bis(trimethylsilyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate; 5-(Trimethylsilyloxy)-2,4-bis(trimethylsilyl)pyrimidine-6-carboxylic acid trimethylsilyl ester; Silylated Barbituric Acid Derivative; TMS-protected pyrimidinetrione
EINECS	Contact for details

Quality Control

Our 1,3-Bis(Trimethylsilyl)-2,6-Dioxo-1,2,3,6-Tetrahydro-4-Pyrimidinecarboxylic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.