Description

2,2-Dimethylbutanedioic Acid Bis(Trimethylsilyl) Ester is a high-purity silylating reagent and a key synthetic intermediate in advanced organic chemistry. This compound is valued for its role in protecting carboxylic acid groups and facilitating derivatization for analytical and synthetic purposes. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex molecules and analytical sample preparation.

Application

• Derivatization Agent for GC/MS Analysis: Used to convert polar carboxylic acids into volatile trimethylsilyl (TMS) esters for improved chromatographic separation and mass spectrometric detection.
• Carboxylic Acid Protection in Organic Synthesis: Serves as a protecting group for dicarboxylic acids during multi-step synthesis of pharmaceuticals and fine chemicals, preventing unwanted side reactions.
• Intermediate for Siloxane and Silicone Chemistry: Acts as a precursor or building block in the synthesis of specialized silicone-based materials and functional siloxanes.
• Reagent in Peptide and Polymer Chemistry: Employed to modify carboxyl termini or side chains in peptide synthesis and to functionalize polymers.
• Catalyst and Ligand Preparation: Utilized in the preparation of metal-organic complexes and catalysts where silyl ester groups are integral to the ligand structure.
• Laboratory Reagent for Analytical Standards: Used to prepare certified reference materials and analytical standards for quality control laboratories.

Basic Information

Product Name	2,2-Dimethylbutanedioic Acid Bis(Trimethylsilyl) Ester
CAS No.	55530-54-6
Molecular Formula	C12H26O4Si2
Molecular Weight	290.50 g/mol
Synonyms	2,2-Dimethylsuccinic Acid Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) 2,2-Dimethylsuccinate; 2,2-Dimethylbutanedioic Acid Bis-O-(trimethylsilyl) Ester; TMS Ester of 2,2-Dimethylsuccinic Acid; Trimethylsilyl 2,2-Dimethylsuccinate; NSC 334087; α,α-Dimethylsuccinic Acid Bis(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Our 2,2-Dimethylbutanedioic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.