Description

2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Glucitol 1-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly functionalized, fully protected derivative of D-glucitol, featuring multiple trimethylsilyl (TMS) groups and a phosphoric acid ester moiety. This compound is a critical advanced synthetic intermediate and protecting group reagent, valued for its ability to impart solubility and stability in complex organic syntheses. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex carbohydrates, nucleosides, and other bioactive molecules.

Application

• Advanced Pharmaceutical Intermediates: Key building block in the multi-step synthesis of complex drug candidates, particularly those with carbohydrate or phosphate ester backbones.
• Carbohydrate Chemistry & Glycoscience: Serves as a fully protected glucitol derivative for the controlled synthesis of oligosaccharides, glycoconjugates, and glycomimetics.
• Nucleoside & Nucleotide Analog Synthesis: Used in the preparation of modified nucleosides and nucleotides for antiviral and anticancer research.
• Protecting Group Strategy: The multiple TMS groups act as robust protecting groups for hydroxyl functions, enabling selective deprotection in complex molecular architectures.
• Agrochemical Research: Intermediate in the development of novel, bioactive compounds with specific sugar-phosphate motifs for crop protection.
• Material Science Precursor: Potential starting material for creating functionalized polymers or surfaces with specific hydrophilic/lipophilic properties.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial-scale production of high-value fine chemicals.

Basic Information

Product Name	2-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-D-Glucitol 1-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	55528-11-5
Molecular Formula	C27H67O9PSi7
Molecular Weight	787.43 g/mol
Synonyms	D-Glucitol, 1-(bis(trimethylsilyl) phosphate), 2,3,4,5,6-pentakis-O-(trimethylsilyl)-; 1-O-(Bis(trimethylsilyl)phosphoryl)-2,3,4,5,6-penta-O-trimethylsilyl-D-glucitol; Pentakis(trimethylsilyl) D-glucitol bis(trimethylsilyl) phosphate; Fully TMS-protected D-glucitol phosphate ester; Hexa(trimethylsilyl) D-glucitol phosphate derivative; Glucitol heptakis(trimethylsilyl) ether phosphate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this high-purity synthetic intermediate is produced and tested under strict quality management systems. We employ advanced analytical techniques including NMR (¹H, ¹³C, ³¹P), HPLC, and GC to ensure structural identity and chemical purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 90.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.