Description

3-O,4-o-Bis(Trimethylsilyl)-1-Deoxo-1-(Methoxyimino)-2-Deoxy-D-Erythro-Pentose 5-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a sophisticated, fully protected pentose derivative, a key building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex nucleoside analogs and modified oligonucleotides, where precise stereochemistry and functional group protection are critical. This compound is essential for pharmaceutical R&D teams and fine chemical manufacturers focused on antiviral, anticancer, and antisense therapeutic development.

Application

• Nucleoside & Nucleotide Analog Synthesis: A critical protected intermediate for the preparation of modified nucleosides used in antiviral and anticancer drug discovery.
• Oligonucleotide Chemistry: Serves as a building block in solid-phase synthesis for creating antisense oligonucleotides and siRNA constructs with specific backbone modifications.
• Carbohydrate Chemistry Research: Used in academic and industrial labs to study glycosylation reactions and synthesize complex sugar moieties for glycoconjugate vaccines.
• Pharmaceutical Intermediate: Employed in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting viral infections and genetic disorders.
• Prodrug Development: The protected phosphate ester functionality makes it valuable for designing prodrug strategies to enhance drug bioavailability.
• Chemical Biology Probes: Utilized to create labeled or modified nucleotides for probing enzymatic mechanisms and studying nucleic acid interactions.

Basic Information

Item	Detail
Product Name	3-O,4-o-Bis(Trimethylsilyl)-1-Deoxo-1-(Methoxyimino)-2-Deoxy-D-Erythro-Pentose 5-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	55520-88-2
Molecular Formula	C20H48N1O7P1Si4
Molecular Weight	554.92 g/mol
Synonyms	1-Deoxo-1-(methoxyimino)-2-deoxy-D-erythro-pentose 5-phosphate, bis(trimethylsilyl) ester, 3,4-bis-O-(trimethylsilyl) derivative; 2-Deoxy-D-erythro-pentose, 1-deoxo-1-(methoxyimino)-, 5-[bis(trimethylsilyl) phosphate], 3,4-bis-O-(trimethylsilyl)-; Protected 1-Methoxyimino-2-deoxypentose 5-phosphate; TMS-protected pentose phosphate oxime; Nucleoside synthesis intermediate 55520-88-2; D-erythro-Pentose, 1-deoxo-1-(methoxyimino)-2-deoxy-, 5-[bis(trimethylsilyl) phosphate], 3,4-bis-O-(trimethylsilyl)-
EINECS	Contact for details

Quality Control

Every batch of this high-value synthetic intermediate is produced and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ³¹P), and mass spectrometry to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and highly volatile nature, store under an inert atmosphere (argon or nitrogen) at -20°C or below. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress and degradation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by ¹H NMR)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.