Description

3-O,4-O,5-o-Tris(Trimethylsilyl)-2-Deoxy-D-Arabino-Hexose 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly specialized, fully protected carbohydrate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a reactive, yet stable, scaffold for the controlled synthesis of complex nucleosides, nucleotides, and other biologically active molecules. This compound is essential for researchers and process chemists in the pharmaceutical and biotechnology sectors, particularly those developing novel antiviral agents, anticancer drugs, and sophisticated nucleotide-based probes.

Application

• Nucleoside/Nucleotide Synthesis: A key protected intermediate for the controlled assembly of modified nucleosides and nucleotides, crucial for antiviral and anticancer drug discovery.
• Pharmaceutical Intermediates: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs) that require specific sugar moiety modifications.
• Bioconjugation & Probe Development: Serves as a building block for creating labeled nucleotides or carbohydrate-based probes used in diagnostic assays and biochemical research.
• Carbohydrate Chemistry Research: Enables the study of glycosylation reactions and the synthesis of complex oligosaccharides under controlled, silyl-protected conditions.
• Process Chemistry & Scale-up: Provides a reliable and high-purity starting material for optimizing and scaling synthetic routes in pilot plant and manufacturing settings.

Basic Information

Product Name	3-O,4-O,5-o-Tris(Trimethylsilyl)-2-Deoxy-D-Arabino-Hexose 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	55520-84-8
Molecular Formula	C24H59NO8PSi5
Molecular Weight	666.27 g/mol
Synonyms	2-Deoxy-D-arabino-hexose 6-(bis(trimethylsilyl) phosphate) 3,4,5-tris(trimethylsilyl) ether; 2-Deoxy-D-glucose 6-(bis(trimethylsilyl) phosphate) 3,4,5-tris(trimethylsilyl) ether; Fully Silylated 2-Deoxy-D-glucose 6-Phosphate; TMS-Protected 2-Deoxyglucose-6-phosphate; Per-TMS 2-Deoxy-D-glucose-6-phosphate; Hexose Derivative CAS 55520-84-8; Nucleoside Synthesis Intermediate 55520-84-8
EINECS	Contact for details

Quality Control

Every batch of 3-O,4-O,5-o-Tris(Trimethylsilyl)-2-Deoxy-D-Arabino-Hexose 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as identity, purity (by NMR/HPLC), and moisture content. Our quality commitment supports compliance in cGMP and research-grade chemical supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions, preferably in a glovebox or using standard Schlenk techniques, to maintain stability and purity. For long-term storage, consider sealing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure (1H NMR, 13C NMR, 31P NMR)
Purity (HPLC)	≥ 95% (Area %)
Purity (NMR)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.