Description

2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Mannopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly functionalized, fully protected derivative of D-mannose, designed for advanced synthetic applications where precise control over reactivity is paramount. This compound is a critical intermediate in the synthesis of complex carbohydrates, nucleosides, and other bioactive molecules, offering exceptional selectivity and stability during multi-step chemical transformations. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and sophisticated chemical probes.

Application

• Advanced Carbohydrate Synthesis: A key protected intermediate for the stereoselective construction of oligosaccharides, glycoconjugates, and glycomimetics.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Chemical Biology & Probe Development: Used to create labeled or modified sugars for studying biological recognition, enzyme mechanisms, and cellular processes.
• Glycochemistry Research: Enables fundamental research in glycosylation reactions, protecting group strategies, and the synthesis of complex natural products.
• Material Science Precursor: Potential use in creating specialized surfaces or polymers with tailored carbohydrate functionalities.

Basic Information

Product Name	2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Mannopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	55520-81-5
Molecular Formula	C24H61O9PSi6
Molecular Weight	693.29 g/mol
Synonyms	α-D-Mannopyranose, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, cyclic phosphite (6:1) with phosphorous acid; Phosphorous Acid Cyclic Ester with 2,3,4,6-Tetrakis-O-(trimethylsilyl)-α-D-mannopyranose; Fully Silylated D-Mannose Phosphite; D-Mannose Tetrakis(trimethylsilyl) Phosphite Ester; 2,3,4,6-Tetra-O-trimethylsilyl-α-D-mannopyranosyl Phosphite; TMS-Mannose Phosphite; Protected Mannosyl Phosphoramidite Precursor
EINECS	Contact for details

Quality Control

Every batch of our 2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Mannopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is manufactured and tested under strict quality management systems. We employ advanced analytical techniques including NMR (¹H, ¹³C, ³¹P), HPLC, and GC to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Anhydrous basis)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.