Description

2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Glucose 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a fully protected derivative of D-glucose, where all hydroxyl groups are silylated, rendering it a highly valuable intermediate for complex carbohydrate and nucleoside synthesis. This compound is specifically engineered to provide exceptional stability and reactivity control in sensitive glycosylation and phosphorylation reactions, crucial for building sophisticated molecular architectures. It is an essential building block for researchers and manufacturers in pharmaceutical development, advanced material science, and specialized organic synthesis requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex nucleoside analogs, antiviral agents, and other bioactive carbohydrate-based molecules.
• Glycochemistry Research: Serves as a protected glucose donor for controlled glycosylation reactions in the study and synthesis of oligosaccharides and glycoconjugates.
• Chemical Biology Probes: Used to create labeled or modified sugar derivatives for studying metabolic pathways and biological recognition processes.
• Material Science: Acts as a monomer or cross-linking agent in the development of novel polymers and functional materials with specific carbohydrate motifs.
• Process Development: Employed in route scouting and optimization for the scalable production of high-value fine chemicals and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Glucose 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	55520-80-4
Molecular Formula	C24H61O9PSi6
Molecular Weight	677.27 g/mol
Synonyms	D-Glucose, 2,3,4,5-tetrakis-O-(trimethylsilyl)-, 6-(bis(trimethylsilyl) phosphate); Per-O-trimethylsilylated D-glucose 6-phosphate; Hexakis(trimethylsilyl) D-glucose 6-phosphate; TMS-Glucose-6-phosphate; Fully protected glucose-6-phosphate; 1,2,3,4,5-Penta-O-trimethylsilyl-D-glucopyranose 6-(bis(trimethylsilyl) phosphate)
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Glucose 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.