Description

2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Glucopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly specialized, fully protected carbohydrate derivative, serving as a critical intermediate in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise control over glycosylation and phosphorylation reactions. It is primarily utilized in the development of complex pharmaceuticals, sophisticated nucleotide analogs, and novel carbohydrate-based materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside analogs, antiviral agents, and other complex bioactive molecules.
• Glycochemistry Research: Enables the controlled synthesis of specific glycosidic linkages for studying carbohydrate-protein interactions and developing glycoconjugates.
• Oligosaccharide Synthesis: Acts as a protected glycosyl donor or acceptor in the multi-step assembly of defined oligosaccharide chains.
• Prodrug Development: Used to create phosphate-protected prodrug forms of therapeutic nucleosides to enhance bioavailability and stability.
• Chemical Biology Probes: Facilitates the creation of labeled or modified sugar nucleotides for enzymatic and metabolic pathway studies.
• Material Science: Potential precursor for creating novel sugar-based polymers or surface coatings with specific properties.

Basic Information

Product Name	2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Glucopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	55520-79-1
Molecular Formula	C24H59O9PSi6
Molecular Weight	683.21 g/mol
Synonyms	α-D-Glucopyranose, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, cyclic phosphite (3:1); 2,3,4,6-Tetra-O-trimethylsilyl-α-D-glucopyranose cyclic phosphite; α-D-Glucopyranose, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, cyclic ester with phosphorous acid; Fully TMS-protected α-D-glucose phosphite; TMS-Glucose Phosphite Ester; Per-TMS-α-D-glucopyranosyl Phosphite; Cyclic Phosphorous Acid Ester of 2,3,4,6-Tetra-O-TMS-α-D-Glucose
EINECS	Contact for details

Quality Control

Every batch of 2-O,3-O,4-O,6-o-Tetrakis(Trimethylsilyl)-α-D-Glucopyranose [Phosphoric Acid Bis(Trimethylsilyl)] Ester is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR (¹H, ¹³C, ³¹P), HPLC, and mass spectrometry to ensure structural identity and high chemical purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and cGMP compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. For long-term storage, consider storing under refrigeration (2-8°C) in a desiccated environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.