Description

Bis(Trimethylsilyl) Hydrogen Phosphate is a versatile organosilicon reagent primarily used as a silylating agent and a key intermediate in advanced chemical synthesis. Its value lies in its ability to introduce the trimethylsilyl (TMS) group, which is crucial for protecting reactive functional groups and modifying compound properties. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require reliable, high-quality intermediates for complex synthesis and process development.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and nucleoside analogs, where it acts as a protecting group for phosphate functionalities.
• Silylating Agent: Employed to derivatize hydroxyl, carboxyl, and other labile hydrogen-containing groups in organic compounds for analysis (e.g., GC-MS) or to alter solubility and stability.
• Polymer & Material Science: Serves as a monomer or modifying agent in the production of specialty silicones, flame retardants, and surface-modifying coatings.
• Agrochemical Synthesis: A key building block in the manufacture of certain pesticides and herbicides that contain organophosphate or organosilicon structures.
• Laboratory Reagent: Utilized in research settings for the preparation of silyl phosphates and other sensitive organometallic compounds.
• Electrolyte Additive: Investigated for use in lithium-ion battery electrolytes to improve stability and performance at electrode interfaces.

Basic Information

Product Name	Bis(Trimethylsilyl) Hydrogen Phosphate
CAS No.	55518-04-2
Molecular Formula	C6H21O4PSi2
Molecular Weight	244.38 g/mol
Synonyms	Hydrogen Bis(trimethylsilyl) Phosphate; Dihydrogen Bis(trimethylsilyl) Phosphate; Phosphoric Acid Bis(trimethylsilyl) Ester; TMS-Phosphate; Bis(TMS) Hydrogen Phosphate; (Trimethylsilyl) Phosphate; Hexamethyldisiloxane Phosphate Derivative; HMDS Hydrogen Phosphate
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl) Hydrogen Phosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC or 31P NMR)	≥ 97.0%
Water Content (Karl Fischer)	≤ 0.5%
Chloride (as Cl)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.