Description

N5-[Bis(Trimethylsilyl)Amino(Imino)Methyl]-N2,N2-Bis(Trimethylsilyl)-L-Ornithine Trimethylsilyl Ester is a highly specialized, multi-silylated derivative of the amino acid L-ornithine, designed for advanced synthetic applications. This compound matters as a critical, protected building block for the controlled synthesis of complex peptides and peptidomimetics, particularly in pharmaceutical research and development. It is essential for chemists and researchers in medicinal chemistry, process development, and fine chemical synthesis who require high-purity, moisture-sensitive intermediates for constructing sophisticated molecular architectures.

Application

• Advanced Peptide Synthesis: Serves as a key protected intermediate for the solid-phase and solution-phase synthesis of complex peptides containing ornithine residues.
• Pharmaceutical R&D (API Intermediates): Used in the research and development of active pharmaceutical ingredients (APIs), especially for candidates targeting metabolic or enzymatic pathways.
• Peptidomimetic Drug Discovery: Acts as a crucial building block for creating non-peptide compounds that mimic the structure and function of natural peptides.
• Bioconjugation and Labeling: The reactive silyl-protected amino groups can be selectively deprotected for site-specific bioconjugation or fluorescent labeling of biomolecules.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for novel therapeutic agents in pilot plant and manufacturing settings.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental studies in organic synthesis, bioorganic chemistry, and chemical biology.

Basic Information

Product Name	N5-[Bis(Trimethylsilyl)Amino(Imino)Methyl]-N2,N2-Bis(Trimethylsilyl)-L-Ornithine Trimethylsilyl Ester
CAS No.	55517-81-2
Molecular Formula	C₂₂H₅₃N₃O₂Si₅
Molecular Weight	552.13 g/mol
Synonyms	L-Ornithine, N5-[bis(trimethylsilyl)amino(imino)methyl]-N2,N2-bis(trimethylsilyl)-, trimethylsilyl ester; N2,N5,Nω-Tris(trimethylsilyl)-L-ornithine trimethylsilyl ester derivative; Silylated L-Ornithine Ester; TMS-Ornithine Derivative; Protected L-Ornithine Building Block; (S)-2,5-Bis(bis(trimethylsilyl)amino)pentanoic Acid Trimethylsilyl Ester (alternative representation); 55517-81-2; N2,N2,N5-Tris(trimethylsilyl)-L-ornithine trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our N5-[Bis(Trimethylsilyl)Amino(Imino)Methyl]-N2,N2-Bis(Trimethylsilyl)-L-Ornithine Trimethylsilyl Ester is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR (¹H and ¹³C) for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening and should be stored in a desiccator. Handle and dispense in a moisture-free environment, such as a glovebox or under a continuous inert gas purge.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Chiral Purity (HPLC)	≥ 99.0% ee (L-Isomer)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.