Description

(24R)-3β,24-Bis(Trimethylsilyloxy)Cholest-5-Ene is a high-purity, organosilicon-protected derivative of cholesterol, serving as a critical synthetic intermediate in advanced organic and pharmaceutical chemistry. This compound is valued for its role in introducing silyl ether protecting groups, which are essential for the selective manipulation of steroid and complex molecule frameworks during multi-step syntheses. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, steroid-based drugs, and sophisticated chemical probes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroid-based therapeutics and active pharmaceutical ingredients (APIs).
• Organic Synthesis Reagent: Used as a protected cholesterol derivative for the selective functionalization of the 3β- and 24- positions in complex molecule construction.
• Biochemical Research: Employed in studies of cholesterol metabolism, membrane biology, and as a precursor for labeled compounds in tracer studies.
• Material Science: Potential precursor for the synthesis of liquid crystals or advanced organic materials with specific steroidal architectures.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	(24R)-3β,24-Bis(Trimethylsilyloxy)Cholest-5-Ene
CAS No.	55517-69-6
Molecular Formula	C33H62O2Si2
Molecular Weight	547.0 g/mol
Synonyms	3β,24-Bis-O-(trimethylsilyl)cholest-5-ene; (24R)-Cholest-5-ene-3β,24-diol, 3,24-bis(trimethylsilyl) ether; 3β,24-Bis(trimethylsiloxy)cholest-5-ene; 24R-Bis-TMS-cholesterol; TMS-protected cholesterol derivative; 55517-69-6; Cholest-5-en-3β,24-diol, bis(trimethylsilyl) ether, (24R)-
EINECS	Contact for details

Quality Control

Our (24R)-3β,24-Bis(Trimethylsilyloxy)Cholest-5-Ene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.