Description

3-O,5-o-Bis(Trimethylsilyl)-6-o-Bis(Trimethylsilyloxy)Phosphinyl-2-Deoxy-D-Arabino-Hexonic Acid 1,4-Lactone CAS NO 55517-62-9 is a sophisticated, organosilicon-protected carbohydrate derivative, specifically a phosphinyl lactone, designed for advanced synthetic chemistry. This compound serves as a critical building block and protecting group reagent in the synthesis of complex nucleosides, nucleotides, and other biologically active molecules. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and fine chemical synthesis who require high-purity, specialized intermediates for precise molecular construction.

Application

• Nucleoside/Nucleotide Analog Synthesis: A key protected intermediate for constructing modified sugar moieties in antiviral and anticancer drug candidates.
• Pharmaceutical Intermediate: Used in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting viral diseases.
• Carbohydrate Chemistry Research: Enables the study and synthesis of novel sugar derivatives with potential therapeutic applications.
• Protecting Group Reagent: The trimethylsilyl (TMS) groups provide selective protection for hydroxyl functions during complex synthetic sequences.
• Agrochemical Development: Serves as a precursor in the synthesis of novel, biologically active compounds for crop protection.
• Process Development & Scale-up: Supports process chemistry teams in developing efficient, scalable routes to target molecules.

Basic Information

Product Name	3-O,5-o-Bis(Trimethylsilyl)-6-o-Bis(Trimethylsilyloxy)Phosphinyl-2-Deoxy-D-Arabino-Hexonic Acid 1,4-Lactone
CAS No.	55517-62-9
Molecular Formula	C21H51O9PSi4
Molecular Weight	598.99 g/mol
Synonyms	2-Deoxy-D-arabino-hexonic acid, 3,5-bis-O-(trimethylsilyl)-6-O-[bis(trimethylsilyl)phosphinyl]-, 1,4-lactone; 3,5-Bis-O-(trimethylsilyl)-6-O-[bis(trimethylsilyloxy)phosphinyl]-2-deoxy-D-arabino-hexono-1,4-lactone; D-Glucose derivative, 3,5-bis-O-TMS-6-O-[bis(TMS)phosphinyl]-2-deoxy-1,4-lactone; TMS-Protected Phosphinyl Lactone; Silylated Carbohydrate Phosphonate Ester Lactone
EINECS	Contact for details

Quality Control

Our production of this high-value synthetic intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity suitable for research and development. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.