Description

n-(Trimethylsilyl)-n-[2-(Trimethylsiloxy)Benzoyl]Glycine Trimethylsilyl Ester is a specialized organosilicon derivative of glycine, designed for advanced synthetic applications. This compound is valued for its role as a versatile silylating agent and protected intermediate, enabling complex organic transformations with high efficiency and selectivity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected glycine derivative in solid-phase and solution-phase peptide synthesis to prevent unwanted side reactions.
• Silylating Agent: Facilitates the introduction of trimethylsilyl (TMS) protecting groups onto sensitive functional groups like carboxylic acids and hydroxyls under mild conditions.
• Organic Synthesis Reagent: Employed in research and development for constructing complex molecular architectures, particularly where moisture-sensitive intermediates are involved.
• Chemical Derivatization: Useful in analytical chemistry for derivatizing compounds to improve their volatility for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis.

Basic Information

Item	Details
Product Name	n-(Trimethylsilyl)-n-[2-(Trimethylsiloxy)Benzoyl]Glycine Trimethylsilyl Ester
CAS No.	55517-53-8
Molecular Formula	C18H31NO4Si3
Molecular Weight	421.70 g/mol
Synonyms	Glycine, N-(trimethylsilyl)-N-[2-(trimethylsiloxy)benzoyl]-, trimethylsilyl ester; N-(Trimethylsilyl)-N-[2-(trimethylsiloxy)benzoyl]glycine trimethylsilyl ester; TMS-Glycine derivative; Tris(trimethylsilyl) glycine benzoyl derivative; 2-[(Trimethylsilyloxy)benzoyl](trimethylsilyl)aminoacetic acid trimethylsilyl ester; N-TMS-N-(2-TMSO-benzoyl)glycine TMS ester
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-n-[2-(Trimethylsiloxy)Benzoyl]Glycine Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) with full specification data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.