Description

2-Methyl-5-(Trimethylsiloxy)-3-[(Trimethylsiloxy)Methyl]-4-Pyridinecarboxylic Acid Trimethylsilyl Ester is a highly functionalized, silyl-protected pyridine derivative that serves as a critical synthetic intermediate. Its value lies in providing a protected, reactive scaffold for constructing complex molecules in advanced pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, where its specific substitution pattern enables precise molecular modifications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the pyridine core for biological activity.
• Ligand and Catalyst Precursor: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and functional polymers due to its derivatizable structure.
• Custom Synthesis and Contract Manufacturing: A valuable substrate for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	2-Methyl-5-(Trimethylsiloxy)-3-[(Trimethylsiloxy)Methyl]-4-Pyridinecarboxylic Acid Trimethylsilyl Ester
CAS No.	55517-52-7
Molecular Formula	C17H33NO5Si3
Molecular Weight	431.78 g/mol
Synonyms	4-Pyridinecarboxylic acid, 2-methyl-5-[(trimethylsilyl)oxy]-3-[[(trimethylsilyl)oxy]methyl]-, trimethylsilyl ester; Trimethylsilyl 2-methyl-5-(trimethylsiloxy)-3-[(trimethylsiloxy)methyl]isonicotinate; 2-Methyl-5-(trimethylsilyloxy)-3-[(trimethylsilyloxy)methyl]isonicotinic acid trimethylsilyl ester; TMS-protected methylhydroxypyridinecarboxylate; Silylated pyridine ester intermediate; CAS 55517-52-7
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-5-(Trimethylsiloxy)-3-[(Trimethylsiloxy)Methyl]-4-Pyridinecarboxylic Acid Trimethylsilyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.