Description

n-Acetyl-n-(Trimethylsilyl)-L-Glutamic Acid Bis(Trimethylsilyl) Ester is a sophisticated, fully protected derivative of L-glutamic acid, designed for advanced synthetic applications. This compound matters because it offers exceptional stability and reactivity control, serving as a crucial building block in complex organic synthesis where sensitive functional groups must be preserved. It is primarily needed by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the production of peptides, peptidomimetics, and other high-value fine chemicals.

Application

• Peptide Synthesis: As a protected glutamic acid derivative for the controlled incorporation of glutamic acid residues into peptide chains without side-chain interference.
• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting neurological or metabolic pathways.
• Prodrug Development: Utilized in the design of prodrugs where the trimethylsilyl ester groups provide lipophilicity and controlled hydrolysis profiles.
• Bioconjugation Chemistry: Serves as a modified amino acid for labeling or linking biomolecules in diagnostic and therapeutic agent development.
• Chemical Biology Research: Used in the study of enzyme mechanisms and protein-protein interactions by introducing stable, non-hydrolyzable glutamic acid analogs.
• Material Science: Potential monomer or modifier for creating specialized polymers with unique degradation or recognition properties.

Basic Information

Product Name	n-Acetyl-n-(Trimethylsilyl)-L-Glutamic Acid Bis(Trimethylsilyl) Ester
CAS No.	55517-49-2
Molecular Formula	C16H35NO5Si3
Molecular Weight	405.70 g/mol
Synonyms	L-Glutamic acid, N-acetyl-N-(trimethylsilyl)-, bis(trimethylsilyl) ester; Ac-Glu(OTMS)-OTMS; N-Acetyl-N-trimethylsilyl-L-glutamic acid bis(trimethylsilyl) ester; N-Acetyl-N-(trimethylsilyl)-L-glutamic acid bis(trimethylsilyl) ester; Fully protected N-acetyl-L-glutamic acid; N-Acetyl-L-glutamic acid N,O,O-tris(trimethylsilyl) derivative; (2S)-2-Acetamido-2-(trimethylsilylamino)-5-[(trimethylsilyl)oxy]-5-oxopentanoic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our n-Acetyl-n-(Trimethylsilyl)-L-Glutamic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and residual solvent analysis, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity (typically >95% by HPLC), and specific impurities are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.