Description

1-(Trimethylsilyl)-5-(Trimethylsiloxy)-2-Piperidinecarboxylic Acid Trimethylsilyl Ester is a highly functionalized, multi-silylated piperidine derivative that serves as a versatile and protected synthetic intermediate. Its value lies in providing a reactive scaffold for constructing complex nitrogen-containing molecules while offering enhanced stability and solubility in organic media through its trimethylsilyl (TMS) protecting groups. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex piperidine-based drug candidates, including potential central nervous system (CNS) agents and receptor modulators.
• Advanced Organic Synthesis: Used in multi-step synthesis to introduce protected carboxylic acid and amine functionalities, facilitating complex molecular construction.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides with tailored biological activity.
• Material Science Precursor: Potential use in the synthesis of specialty polymers or functionalized surfaces where the silyl groups can influence material properties.
• Catalyst Ligand Synthesis: Can be utilized to create novel nitrogen-containing ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic & R&D Laboratories: A valuable reagent for methodological development in synthetic organic chemistry, particularly in studies involving protective group strategies.

Basic Information

Product Name	1-(Trimethylsilyl)-5-(Trimethylsiloxy)-2-Piperidinecarboxylic Acid Trimethylsilyl Ester
CAS No.	55517-48-1
Molecular Formula	C16H35NO3Si3
Molecular Weight	389.71 g/mol
Synonyms	2-Piperidinecarboxylic acid, 1-(trimethylsilyl)-5-[(trimethylsilyl)oxy]-, trimethylsilyl ester; Trimethylsilyl 1-(trimethylsilyl)-5-(trimethylsiloxy)-2-piperidinecarboxylate; 1-TMS-5-TMSO-2-Piperidinecarboxylic Acid TMS Ester; Fully Silylated Nipecotic Acid Derivative; 1,2,5-Tris(trimethylsilyl) Nipecotate; TMS-Nipecotic Acid TMS Ester; CAS 55517-48-1
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-5-(Trimethylsiloxy)-2-Piperidinecarboxylic Acid Trimethylsilyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. While typically supplied at technical or research grade, we can provide material tailored to specific purity requirements. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Typical)
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.