Description

2-Oxo-3-(Trimethylsilyl)Succinic Acid Bis(Trimethylsilyl) Ester is a high-value organosilicon intermediate featuring a unique silyl-protected α-keto acid ester structure. This compound is critical for advanced organic synthesis, offering superior reactivity and selectivity in complex molecular construction. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly those requiring silyl-protected functional groups for stepwise assembly.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its reactive keto-ester moiety enables the creation of new active scaffolds.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the development of specialty silicone polymers and hybrid organic-inorganic materials.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for stereoselective aldol reactions, Michael additions, and other carbon-carbon bond-forming transformations.
• Protecting Group Strategy: The bis(trimethylsilyl) ester groups provide temporary protection for carboxylic acid functionalities during multi-step synthetic sequences.

Basic Information

Product Name	2-Oxo-3-(Trimethylsilyl)Succinic Acid Bis(Trimethylsilyl) Ester
CAS No.	55517-46-9
Molecular Formula	C14H30O5Si3
Molecular Weight	374.66 g/mol
Synonyms	3-(Trimethylsilyl)-2-oxobutanedioic acid bis(trimethylsilyl) ester; Bis(trimethylsilyl) 3-(trimethylsilyl)-2-oxosuccinate; 2-Oxo-3-(trimethylsilyl)butanedioic acid bis(trimethylsilyl) ester; TMS-protected oxosuccinate ester; Silylated α-ketoglutarate derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 2-Oxo-3-(Trimethylsilyl)Succinic Acid Bis(Trimethylsilyl) Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure product identity, purity, and consistency for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA) including assay (HPLC), identity confirmation (IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.