Description

Glycine, n-(2-Methyl-1-Oxo-2-Butenyl)-n-(Trimethylsilyl)-, Trimethylsilyl Ester, (E)- is a specialized organosilicon-protected glycine derivative, a key building block in advanced organic synthesis. This compound is valued for its role in introducing protected amino acid functionalities under mild conditions, enabling the synthesis of complex peptides and other bioactive molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial synthon in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators with amino acid backbones.
• Peptide Synthesis: Acts as a protected glycine equivalent in solid-phase and solution-phase peptide synthesis (SPPS), facilitating complex sequence assembly.
• Chemical Biology Probes: Employed in the creation of labeled or modified amino acids for studying biological pathways and protein function.
• Material Science: A potential precursor for silicon-containing hybrid polymers and advanced coatings with tailored properties.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and catalysis research.

Basic Information

Product Name	Glycine, n-(2-Methyl-1-Oxo-2-Butenyl)-n-(Trimethylsilyl)-, Trimethylsilyl Ester, (E)-
CAS No.	55517-45-8
Molecular Formula	C13H27NO3Si2
Molecular Weight	301.53 g/mol
Synonyms	(E)-N-(2-Methyl-1-oxo-2-butenyl)-N-(trimethylsilyl)glycine trimethylsilyl ester; N-(3-Methylcrotonoyl)-N-(trimethylsilyl)glycine trimethylsilyl ester; 3-Methylcrotonoylglycine bis(trimethylsilyl) ester; Glycine, N-(3-methyl-1-oxo-2-butenyl)-N-(trimethylsilyl)-, bis(trimethylsilyl) ester; TMS-Glycine derivative; Silylated glycine derivative; Protected glycine synthon
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to strict in-process controls to ensure batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including NMR, HPLC, and GC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isomeric Purity (GC/HPLC)	≥ 98.0% (E)-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.