Description

4-[Bis(Trimethylsilyl)Amino]-2-(Trimethylsilyl)Isoxazolidin-3-One is a highly functionalized, organosilicon-protected heterocyclic compound that serves as a versatile building block in advanced organic synthesis. Its value lies in providing a masked amino and carbonyl functionality, enabling complex multi-step reactions under mild conditions where traditional protecting groups may fail. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for constructing complex nitrogen-containing scaffolds.

Application

• Pharmaceutical Intermediate: Key synthon for the construction of complex nitrogen heterocycles found in active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used in the synthesis of peptide analogs and protease inhibitors by providing protected amino acid equivalents.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides requiring specific isoxazolidinone or silylated amine motifs.
• Material Science Precursor: Potential monomer or intermediate for synthesizing specialized silicon-containing polymers and coatings.
• Asymmetric Synthesis: Chiral auxiliary or substrate in stereoselective reactions to create enantiomerically pure compounds.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed and other metal-mediated coupling reactions to form complex molecular architectures.

Basic Information

Product Name	4-[Bis(Trimethylsilyl)Amino]-2-(Trimethylsilyl)Isoxazolidin-3-One
CAS No.	55517-42-5
Molecular Formula	C12H30N2O2Si3
Molecular Weight	330.65 g/mol
Synonyms	4-[Bis(trimethylsilyl)amino]-2-(trimethylsilyl)-3-isoxazolidinone; 2-(Trimethylsilyl)-4-[bis(trimethylsilyl)amino]-3-isoxazolidinone; 3-Isoxazolidinone, 4-[bis(trimethylsilyl)amino]-2-(trimethylsilyl)-; Tris(trimethylsilyl) Protected Isoxazolidinone; N,O-Bis(trimethylsilyl) Protected Amino Isoxazolidinone
EINECS	Contact for details

Quality Control

Our production of 4-[Bis(Trimethylsilyl)Amino]-2-(Trimethylsilyl)Isoxazolidin-3-One adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.