Description

2,2-Bis(Trimethylsiloxy)Acetic Acid Trimethylsilyl Ester is a specialized organosilicon compound, primarily valued as a versatile silylating agent and a key protected intermediate in advanced organic synthesis. Its unique structure, featuring multiple trimethylsilyl groups, makes it highly effective for introducing silyl protecting groups onto sensitive functional groups like carboxylic acids and alcohols. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for complex, multi-step synthesis.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for protecting sensitive carboxylic acid moieties during complex reaction sequences.
• Silylating Agent: Employed to derivatize compounds for analysis (e.g., in GC-MS) or to impart volatility and thermal stability.
• Fine Chemical Synthesis: Serves as a crucial building block for constructing complex molecules in agrochemicals, fragrances, and specialty polymers.
• Silicon Chemistry Research: A valuable reagent for developing new organosilicon compounds and studying silylation reaction mechanisms.
• Protecting Group Chemistry: Specifically used for the protection of α-hydroxy or α-keto acids in multi-step organic synthesis.

Basic Information

Product Name	2,2-Bis(Trimethylsiloxy)Acetic Acid Trimethylsilyl Ester
CAS No.	55517-38-9
Molecular Formula	C11H28O4Si3
Molecular Weight	308.59 g/mol
Synonyms	Acetic acid, 2,2-bis(trimethylsiloxy)-, trimethylsilyl ester; Trimethylsilyl 2,2-bis(trimethylsiloxy)acetate; Tris(trimethylsilyl) acetonedicarboxylate; 2,2-Bis(trimethylsilyloxy)acetic acid trimethylsilyl ester; TMS-DK; Acetonedicarboxylic acid tris(trimethylsilyl) ester; Tris-O-(trimethylsilyl) acetonedicarboxylate
EINECS	Contact for details

Quality Control

Our 2,2-Bis(Trimethylsiloxy)Acetic Acid Trimethylsilyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.