Description

α-Oxobenzeneacetic Acid Trimethylsilyl Ester is a specialized organosilicon reagent used as a key protecting group and synthetic intermediate in advanced organic synthesis. This compound is valued for its ability to mask reactive carboxylic acid functionalities under a variety of reaction conditions, enabling complex multi-step syntheses. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the production of high-value fine chemicals and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a crucial building block and protecting group in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Employed in the research and development of novel pesticides, herbicides, and plant growth regulators where sensitive functional groups require protection.
• Peptide Chemistry: Used to protect carboxylic acid moieties on amino acids during solid-phase and solution-phase peptide synthesis.
• Material Science Research: Acts as a precursor or modifying agent in the development of specialty polymers and silicon-containing advanced materials.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis laboratories for creating novel carbon-silicon bonds and exploring new reaction pathways.
• Fine Chemical Production: Facilitates the synthesis of complex fragrance compounds, flavors, and other high-value specialty chemicals.

Basic Information

Item	Detail
Product Name	α-Oxobenzeneacetic Acid Trimethylsilyl Ester
CAS No.	55517-36-7
Molecular Formula	C11H14O3Si
Molecular Weight	222.31 g/mol
Synonyms	Trimethylsilyl Phenylglyoxylate; Phenylglyoxylic Acid Trimethylsilyl Ester; (Trimethylsilyl) 2-oxo-2-phenylacetate; 2-Oxo-2-phenylacetic Acid Trimethylsilyl Ester; Benzoylformic Acid Trimethylsilyl Ester; TMS Phenylglyoxylate; α-Ketophenylacetic Acid Trimethylsilyl Ester; CAS 55517-36-7
EINECS	Contact for details

Quality Control

Every batch of α-Oxobenzeneacetic Acid Trimethylsilyl Ester is manufactured and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by GC/HPLC), identity confirmation, and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical intermediate use, and we can accommodate custom purity grades or analytical requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.