Description

n-[(E)-2-Methyl-1-Oxo-2-Butenyl]Glycine Trimethylsilyl Ester is a specialized organosilicon-protected amino acid derivative, serving as a critical synthetic intermediate. Its primary value lies in enabling advanced organic synthesis, particularly in peptide and heterocyclic chemistry, by offering a protected glycine moiety with enhanced solubility and reactivity in non-polar media. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, moisture-sensitive building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel peptide-based drugs and protease inhibitors.
• Agrochemical Synthesis: Used in the research and development of new active ingredients, such as herbicides and fungicides with specific amino acid backbones.
• Peptide Mimetics Research: Facilitates the creation of peptidomimetics and constrained peptides for drug discovery programs.
• Organometallic & Catalyst Ligand Synthesis: Acts as a precursor for creating specialized ligands used in asymmetric catalysis.
• Advanced Material Precursor: Employed in the development of silicon-containing polymers and hybrid organic-inorganic materials.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic synthesis and scale-up process optimization.

Basic Information

Product Name	n-[(E)-2-Methyl-1-Oxo-2-Butenyl]Glycine Trimethylsilyl Ester
CAS No.	55517-35-6
Molecular Formula	C10H19NO3Si
Molecular Weight	229.35 g/mol
Synonyms	Glycine, N-[(1E)-2-methyl-1-oxo-2-buten-1-yl]-, trimethylsilyl ester; (E)-2-Methyl-1-oxo-2-butenylglycine trimethylsilyl ester; Trimethylsilyl (E)-2-methylcrotonoylglycinate; N-(2-Methyl-1-oxo-2-butenyl)glycine trimethylsilyl ester; TMS ester of N-tigloylglycine; N-Tigloylglycine trimethylsilyl ester; 55517-35-6; Tigloylglycine TMS ester
EINECS	Contact for details

Quality Control

Our n-[(E)-2-Methyl-1-Oxo-2-Butenyl]Glycine Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our commitment to quality supports applications requiring high-purity intermediates under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.